Zonisamide

Zonisamide belongs to the sulphonamide family and is a new generation antiepileptic. It is used to treat partial epileptic seizures, i.e. seizures which are not accompanied by abnormal consciousness. This medicine is prescribed to adults from 16 years old onwards.

How does zonisamide work?

The mechanism of action of zonisamide is not fully understood. It is believed to act by blocking the sodium channels involved in the propagation of nerve impulses. They therefore act on the neuronal overexcitability which occurs in an epileptic attack.

Do they have contraindications or precautions?

The main adverse effects of the zonisamide are persistent fatigue, dizziness and intellectual problems, particularly difficulties finding words. It can also cause weight loss or even anorexia.

Sources:

• Merck Manual, 4^th edition
• Institute for pharmaceutical and biological sciences – Lyon faculty of pharmacy