Methylergometrine

Methylergometrine is an ocytocin-like molecule. As such it provokes or stimulates uterine contractions. It is extracted from a rye ergot alkaloid, from a fungal parasite on the cereal.

How does methylergometrine work

Methylergometrine is used post-partum (immediately afterdelivery) to prevent or treat uterine hypotonia or bleeding. It is administered orally or as an injectable solution. It is also used to treat uterine haemorrhages after childbirth, a caesarian section or termination of pregnancy. Its action is mostly uterotonic. In other words it stimulates contractions by acting directly on the smooth muscle of the uterus, the myometrium. This medicine therefore increases the tone, frequency and amplitude of contractions. Its maximum effect occurs 2 to 5 minutes after intramuscular injection. The effect is continued for up to 4 to 6 hours.

Do they have contraindications or precautions?

Administration of methylergometrine can cause rises in blood pressure, arrhythmias and coronary artery spasm in the mother. It must not be given to people who are hypertensive. Precautions are also required in renal impairment, liver impairment or in patients with cardiovascular risk factors.

Sources:

• Vidal, 2010 edition 2010;
• Dictionnaire de Médecine: gynécologie-obstétrique, PUF