Intestinal absorption inhibitor

The intestinal absorption inhibitors are used for excess cholesterol either alone or in combination with a statin. They are the latest generation of lipid-lowering agents.

How do the intestinal absorption inhibitors work?

The intestinal absorption inhibitors have a very specific mechanism of action. Unlike statins which work in the liver, these medicines target the other entry point for cholesterol into the body: the intestine. Somehow they block this access. For this reason doctors regularly emphasise that these compounds have a complementary action to the action of statins.

Do they have contraindications or precautions?

The intestinal absorption inhibitors are generally well tolerated. Occasional cases of muscle damage (rhabdomyolysis) have been reported, however, with these treatments, either used alone or in combination with a statin. They can also cause a rise in some liver enzymes, the serum transaminases.

Sources:

• Merck Manual – 4^th edition
• French National Health Authority