Imidazoles

The imidazoles are antibiotics which have bactericidal action. They are mostly used in the treatment of some pneumonias, lung, cerebral, and liver abscesses, purulent peritonitis and pleurisy. They are also prescribed for bacterial vaginosis and peptic ulceration. They can be administered intravenously or orally.

How do the imidazoles work?

The imidazoles inhibit nucleic acid synthesis. This applies both to deoxyribonucleic acid (DNA) and to ribonucleic acid (RNA). As a result, the pathogenic bacterial cells die.

Do they have contraindications or precautions?

They are generally well tolerated. However, neurological side effects may occur in rare cases. These antibiotics are contraindicated during pregnancy andbreast-feeding.

Source: Necker Children's Hospital, department of infectious and tropical diseases, 5 January 2007